Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Astrocyte
DISEASE(S): Alzheimer's Disease
SUBMITTER: Jinsoo Seo
LAB HEAD: Jinsoo Seo
PROVIDER: PXD045298 | Pride | 2023-09-12
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
ApoE3_astrocytes_1.mgf | Mgf | |||
ApoE3_astrocytes_1.msf | Msf | |||
ApoE3_astrocytes_1.mzML | Mzml | |||
ApoE3_astrocytes_1.mzid.gz | Mzid | |||
ApoE3_astrocytes_1.raw | Raw |
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Cell reports 20230929 10
Recent developments in genome sequencing have expanded the knowledge of genetic factors associated with late-onset Alzheimer's disease (AD). Among them, genetic variant ε4 of the APOE gene (APOE4) confers the greatest disease risk. Dysregulated glucose metabolism is an early pathological feature of AD. Using isogenic ApoE3 and ApoE4 astrocytes derived from human induced pluripotent stem cells, we find that ApoE4 increases glycolytic activity but impairs mitochondrial respiration in astrocytes. U ...[more]