Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Rebecca Fry
PROVIDER: E-GEOD-5301 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Fry Rebecca C RC DeMott Michael S MS Cosgrove Joseph P JP Begley Thomas J TJ Samson Leona D LD Dedon Peter C PC
BMC genomics 20061212
<h4>Background</h4>Upon exposure to agents that damage DNA, Saccharomyces cerevisiae undergo widespread reprogramming of gene expression. Such a vast response may be due not only to damage to DNA but also damage to proteins, RNA, and lipids. Here the transcriptional response of S. cerevisiae specifically induced by DNA damage was discerned by exposing S. cerevisiae to a panel of three "radiomimetic" enediyne antibiotics (calicheamicin gamma1I, esperamicin A1 and neocarzinostatin) that bind speci ...[more]