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Epigenome analysis of smoking in peripheral blood mononuclear cells (PBMC) samples

ABSTRACT: Genome wide DNA methylation profiling of smokers and non-smokers in PBMC samples. The Illumina Infinium 450k Human DNA methylation Beadchip v1.1 was used to obtain DNA methylation profiles across 485,577 CpGs in PBMC samples. Samples included 50 smokers and 61 non-smokers. Bisulfite converted DNA from the 111 samples were hybridized to the Illumina Infinium 450k Human Methylation Beadchip v1.1

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Philibert 

PROVIDER: E-GEOD-53045 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women.

Dogan Meeshanthini V MV   Shields Bridget B   Cutrona Carolyn C   Gao Long L   Gibbons Frederick X FX   Simons Ronald R   Monick Martha M   Brody Gene H GH   Tan Kai K   Beach Steven R H SR   Philibert Robert A RA  

BMC genomics 20140222

<h4>Background</h4>Regular smoking is associated with a wide variety of syndromes with prominent inflammatory components such as cancer, obesity and type 2 diabetes. Heavy regular smoking is also associated with changes in the DNA methylation of peripheral mononuclear cells. However, in younger smokers, inflammatory epigenetic findings are largely absent which suggests the inflammatory response(s) to smoking may be dose dependent. To help understand whether peripheral mononuclear cells have a ro  ...[more]

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