Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse carotid bodies from A/J vs.DBA/2J


ABSTRACT: We hypothesize that gene expression in the CBs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes. More specifically, (1) genes related to CB function are expressed less in the A/J mice compared to DBA/2J mice; (2) gene expression levels of morphogenic and trophic factors of the CB maybe significantly lower in the A/J mice than the DBA/2J mice. In order to test these hypotheses, we utilized microarray analysis to examine transcriptional differences between CBs of both strains of mice. Experiment Overall Design: . This study utilizes microarray analysis to test these hypotheses. Three sets of CBs were harvested from both strains. RNA was isolated and used for global gene expression profiling (Affymetrix Mouse 430 2.0 array). Statistically significant gene expression was determined as a minimum 6 counts of 9 pairwise comparisons, minimum 1.5-fold change, and p < 0.05.

ORGANISM(S): Mus musculus

SUBMITTER: Alexander Balbir 

PROVIDER: E-GEOD-5313 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice.

Balbir Alexander A   Lee Hannah H   Okumura Mariko M   Biswal Shyam S   Fitzgerald Robert S RS   Shirahata Machiko M  

American journal of physiology. Lung cellular and molecular physiology 20061110 3


The carotid body (CB) is the primary hypoxic chemosensory organ. Its hypoxic response appears to be genetically controlled. We have hypothesized that: 1) genes related to CB function are expressed less in the A/J mice (low responder to hypoxia) compared with DBA/2J mice (high responder to hypoxia); and 2) gene expression levels of morphogenic and trophic factors of the CB are significantly lower in the A/J mice than DBA/2J mice. This study utilizes microarray analysis to test these hypotheses. T  ...[more]

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