Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Branca Cavaco
PROVIDER: E-GEOD-53157 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas.
Pita J M JM Banito A A Cavaco B M BM Leite V V
British journal of cancer 20091006 10
<h4>Background</h4>Poorly differentiated thyroid carcinomas (PDTC) represent a heterogeneous, aggressive entity, presenting features that suggest a progression from well-differentiated carcinomas. To elucidate the mechanisms underlying such progression and identify novel therapeutic targets, we assessed the genome-wide expression in normal and tumour thyroid tissues.<h4>Methods</h4>Microarray analyses of 24 thyroid carcinomas - 7 classic papillary, 8 follicular variants of papillary (fvPTC), 4 f ...[more]
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