Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Philip Uren
PROVIDER: E-GEOD-53220 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Tamim Saleh S Vo Dat T DT Uren Philip J PJ Qiao Mei M Bindewald Eckart E Kasprzak Wojciech K WK Shapiro Bruce A BA Nakaya Helder I HI Burns Suzanne C SC Araujo Patricia R PR Nakano Ichiro I Radek Agnes J AJ Kuersten Scott S Smith Andrew D AD Penalva Luiz O F LO
PloS one 20140122 1
miR-137 plays critical roles in the nervous system and tumor development; an increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate the potential of miR-137 in glioblastoma therapy, we conducted genome-wide target mapping in glioblastoma cells by measuring the level of association between PABP and mRNAs in cells transfected with miR-137 mimics vs. controls via RIPSeq. Impact on mRNA levels was also measured by RNASeq. B ...[more]