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The role of PKCtheta in Epithelial to Mesenchymal Transistion

ABSTRACT: Epithelial to mesenchymal transition (EMT) is activated during cancer invasion and metastasis, enriches for cancer stem cells (CSCs), and contributes to therapeutic resistance and disease recurrence. Signal transduction kinases play a pivotal role as chromatin-anchored proteins in eukaryotes. Here we report for the first time that protein kinase C-theta (PKC-θ) regulates EMT by acting as a critical chromatin-anchored switch for inducible genes. Genome-wide transcriptome analysis identifies a unique cohort of inducible PKC-θ-sensitive genes in MCF7 cells stimulated with phorbol ester. MCF7 Cells treated with mock or siRNA against PKCtheta were left unstimulated or stimulated with PMA. No replicates.

ORGANISM(S): Homo sapiens

SUBMITTER: Kristine Hardy 

PROVIDER: E-GEOD-53267 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Chromatinized protein kinase C-θ directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells.

Zafar Anjum A   Wu Fan F   Hardy Kristine K   Li Jasmine J   Tu Wen Juan WJ   McCuaig Robert R   Harris Janelle J   Khanna Kum Kum KK   Attema Joanne J   Gregory Philip A PA   Goodall Gregory J GJ   Harrington Kirsti K   Dahlstrom Jane E JE   Boulding Tara T   Madden Rebecca R   Tan Abel A   Milburn Peter J PJ   Rao Sudha S  

Molecular and cellular biology 20140602 16

Epithelial to mesenchymal transition (EMT) is activated during cancer invasion and metastasis, enriches for cancer stem cells (CSCs), and contributes to therapeutic resistance and disease recurrence. Signal transduction kinases play a pivotal role as chromatin-anchored proteins in eukaryotes. Here we report for the first time that protein kinase C-theta (PKC-θ) promotes EMT by acting as a critical chromatin-anchored switch for inducible genes via transforming growth factor β (TGF-β) and the key  ...[more]

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