Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of human breast cancers and lung metastatis


ABSTRACT: Validation of lung metastasis signature (LMS) and its association with risk of developing lung metastasis and with primary tumor size. Experiment Overall Design: 58 tumor samples

ORGANISM(S): Homo sapiens

SUBMITTER: Andy Minn 

PROVIDER: E-GEOD-5327 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Lung metastasis genes couple breast tumor size and metastatic spread.

Minn Andy J AJ   Gupta Gaorav P GP   Padua David D   Bos Paula P   Nguyen Don X DX   Nuyten Dimitry D   Kreike Bas B   Zhang Yi Y   Wang Yixin Y   Ishwaran Hemant H   Foekens John A JA   van de Vijver Marc M   Massagué Joan J  

Proceedings of the National Academy of Sciences of the United States of America 20070409 16


The association between large tumor size and metastatic risk in a majority of clinical cancers has led to questions as to whether these observations are causally related or whether one is simply a marker for the other. This is partly due to an uncertainty about how metastasis-promoting gene expression changes can arise in primary tumors. We investigated this question through the analysis of a previously defined "lung metastasis gene-expression signature" (LMS) that mediates experimental breast c  ...[more]

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