Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andy Minn
PROVIDER: E-GEOD-5327 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Minn Andy J AJ Gupta Gaorav P GP Padua David D Bos Paula P Nguyen Don X DX Nuyten Dimitry D Kreike Bas B Zhang Yi Y Wang Yixin Y Ishwaran Hemant H Foekens John A JA van de Vijver Marc M Massagué Joan J
Proceedings of the National Academy of Sciences of the United States of America 20070409 16
The association between large tumor size and metastatic risk in a majority of clinical cancers has led to questions as to whether these observations are causally related or whether one is simply a marker for the other. This is partly due to an uncertainty about how metastasis-promoting gene expression changes can arise in primary tumors. We investigated this question through the analysis of a previously defined "lung metastasis gene-expression signature" (LMS) that mediates experimental breast c ...[more]