Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNAseq Replicate experiments from PD38 and PD79 IMR90s

ABSTRACT: RNAseq replicate in Proliferating and Senescent IMR90s We used RNAseq to examine RNA levels in human IMR90 replicative senescence (RS)

ORGANISM(S): Homo sapiens

SUBMITTER: Shelley Berger

PROVIDER: E-GEOD-53330 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

H3K9me3 ChIPseq experiments from PD IMR90s

Project description:H3K9me3 ChIPseq in Proliferating and Senescent IMR90s We used ChIP-seq to examine the global binding of H3K9me3 in human IMR90 replicative senescence (RS) and oncogene-induced (OIS)

2014-12-15 | E-GEOD-53329 | biostudies-arrayexpress

RNAseq Replicate experiments from PD38 and PD79 IMR90s

Project description:RNAseq replicate in Proliferating and Senescent IMR90s

2014-12-15 | GSE53330 | GEO

H3K9me3 ChIPseq experiments from PD IMR90s

Project description:H3K9me3 ChIPseq in Proliferating and Senescent IMR90s

2014-12-15 | GSE53329 | GEO

Expression data from proliferating and senescent IMR90 cells

Project description:Total RNA was isolated from proliferating and senescent IMR90 cells to compare gene-expression to the changes in nucleolus-association in proliferating and senescent IMR90 cells.

2017-06-18 | GSE80447 | GEO

Lamin B1 ChIPseq experiments from ER:RAS IMR90s

Project description:Lamin B1 from OIS IMR90s We used ChIP-seq to examine the global binding of Lamin B1 in human IMR90 oncogene-induced senescence

2014-12-15 | E-GEOD-53331 | biostudies-arrayexpress

Expression data from PD32 and PD88 IMR90

Project description:IMR90 cells were passaged until replicative senescence and compared with proliferating cells. We used RNA-Seq to detail the global programme of gene expression in human IMR90 replicative induced senescence

2014-11-26 | E-GEOD-53356 | biostudies-arrayexpress

Expression data from PD32 and PD88 IMR90

Project description:IMR90 cells were passaged until replicative senescence and compared with proliferating cells.

2014-11-26 | GSE53356 | GEO

Genome-wide methylation maps for Proliferating and Senescent cells

Project description:Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence imposes a limit on proliferative potential that all cancer cells must bypass. Compared to proliferating cells, senescent cells exhibit marked chromatin re-organization. Here we show by whole-genome single-nucleotide bisulfite sequencing that replicative senescent human cells exhibit widespread alterations in their DNA methylome. These changes are linked to mislocalization of the maintenance DNA methyltransferase (DNMT1) in cells approaching senescence, altered replication-coupled DNA methylation and de-repression of repetitive satellite sequences. Deficiency of DNMT1 triggers chromatin changes characteristic of senescence and expression of satellite sequences. Most importantly, but paradoxically, gains and losses of methylation in replicative senescence are similar to those in cancer, and this M-bM-^@M-^XreprogrammedM-bM-^@M-^Y methylation landscape is largely retained when cells escape or bypass senescence. In sum, altered regulation of DNMT1 in cells approaching replicative senescence contributes to changes in chromatin structure and function. Consequently, if senescent cells escape the proliferative barrier, they already harbor epigenetic changes likely to promote malignancy. Examination of methylation status in IMR90 cells

2013-11-25 | E-GEOD-48580 | biostudies-arrayexpress

Expression profiling of etoposide-induced senescent cells

Project description:We report here the RNA-seq data of proliferating IMR90 cells and etoposide-induced senescent cells with control or cGAS knockdown

2017-08-14 | GSE99028 | GEO

Homo sapiens

Project description:Expression data from proliferating and senescent IMR90 cells

| PRJNA318919 | ENA