Transcriptional response of Candida albicans to oral epithelial cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Candida albicans
SUBMITTER: Hyunsook Park
PROVIDER: E-GEOD-5340 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptional responses of candida albicans to epithelial and endothelial cells.
Park Hyunsook H Liu Yaoping Y Solis Norma N Spotkov Joshua J Hamaker Jessica J Blankenship Jill R JR Yeaman Michael R MR Mitchell Aaron P AP Liu Haoping H Filler Scott G SG
Eukaryotic cell 20090821 10
Candida albicans interacts with oral epithelial cells during oropharyngeal candidiasis and with vascular endothelial cells when it disseminates hematogenously. We set out to identify C. albicans genes that govern interactions with these host cells in vitro. The transcriptional response of C. albicans to the FaDu oral epithelial cell line and primary endothelial cells was determined by microarray analysis. Contact with epithelial cells caused a decrease in transcript levels of genes related to pr ...[more]
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