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Kat2a regulates hippocampal memory formation [small RNA-seq]

ABSTRACT: We sequenced small RNAs from 12 samples extracted from mouse CA1 tissue to generate the first CA1-specific murine miRNome under normal and Kat2a-loss-of-function conditions. Samples were divded in 4 groups: A: Control (n=6), C: Kat2a cKO naÃ¯ve (n=6)

ORGANISM(S): Mus musculus

SUBMITTER: Andre Fischer

PROVIDER: E-GEOD-53427 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation.

Stilling Roman M RM Rönicke Raik R Benito Eva E Urbanke Hendrik H Capece Vincenzo V Burkhardt Susanne S Bahari-Javan Sanaz S Barth Jonas J Sananbenesi Farahnaz F Schütz Anna L AL Dyczkowski Jerzy J Martinez-Hernandez Ana A Kerimoglu Cemil C Dent Sharon Y R SY Bonn Stefan S Reymann Klaus G KG Fischer Andre A

The EMBO journal 20140714 17

Neuronal histone acetylation has been linked to memory consolidation, and targeting histone acetylation has emerged as a promising therapeutic strategy for neuropsychiatric diseases. However, the role of histone-modifying enzymes in the adult brain is still far from being understood. Here we use RNA sequencing to screen the levels of all known histone acetyltransferases (HATs) in the hippocampal CA1 region and find that K-acetyltransferase 2a (Kat2a)--a HAT that has not been studied for its role ...[more]

PMID: 25024434

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