Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Horatiu Voicu
PROVIDER: E-GEOD-53480 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Polito Vinicia A VA Li Hongmei H Martini-Stoica Heidi H Wang Baiping B Yang Li L Xu Yin Y Swartzlander Daniel B DB Palmieri Michela M di Ronza Alberto A Lee Virginia M-Y VM Sardiello Marco M Ballabio Andrea A Zheng Hui H
EMBO molecular medicine 20140901 9
Accumulating evidence implicates impairment of the autophagy-lysosome pathway in Alzheimer's disease (AD). Recently discovered, transcription factor EB (TFEB) is a molecule shown to play central roles in cellular degradative processes. Here we investigate the role of TFEB in AD mouse models. In this study, we demonstrate that TFEB effectively reduces neurofibrillary tangle pathology and rescues behavioral and synaptic deficits and neurodegeneration in the rTg4510 mouse model of tauopathy with no ...[more]