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Zrf1 is required to establish and maintain neural progenitor identity (ChIP-Seq)

ABSTRACT: We report ChIP-seq data for Zrf1 and Ring1B occupancy in NPC Examination and comparison of DNA binding profile of Zrf1 and Ring1B in NPC

ORGANISM(S): Mus musculus

SUBMITTER: Luciano Di Croce

PROVIDER: E-GEOD-53540 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Zrf1 is required to establish and maintain neural progenitor identity.

Aloia Luigi L Di Stefano Bruno B Sessa Alessandro A Morey Lluis L Santanach Alexandra A Gutierrez Arantxa A Cozzuto Luca L Benitah Salvador Aznar SA Graf Thomas T Broccoli Vania V Di Croce Luciano L

Genes & development 20140101 2

The molecular mechanisms underlying specification from embryonic stem cells (ESCs) and maintenance of neural progenitor cells (NPCs) are largely unknown. Recently, we reported that the Zuotin-related factor 1 (Zrf1) is necessary for chromatin displacement of the Polycomb-repressive complex 1 (PRC1). We found that Zrf1 is required for NPC specification from ESCs and that it promotes the expression of NPC markers, including the key regulator Pax6. Moreover, Zrf1 is essential to establish and maint ...[more]

PMID: 24449271

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