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Targeted chromatin profiling reveals novel enhancers in Ig heavy and light chain loci.

ABSTRACT: Chip-chip from pro-B cells from Rag1KO mice for H3K27ac and RNA Pol II Identification of novel enhancers from Ig heavy and light chain loci Rag1KO pro-B epigenetic landscape at Ig heavy and light chain loci

ORGANISM(S): Mus musculus

SUBMITTER: Eugene Oltz

PROVIDER: E-GEOD-53766 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci.

Predeus Alexander V AV Gopalakrishnan Suhasni S Huang Yue Y Tang Jun J Feeney Ann J AJ Oltz Eugene M EM Artyomov Maxim N MN

Journal of immunology (Baltimore, Md. : 1950) 20131218 3

The assembly and expression of mouse Ag receptor genes are controlled by a collection of cis-acting regulatory elements, including transcriptional promoters and enhancers. Although many powerful enhancers have been identified for Ig (Ig) and TCR (Tcr) loci, it remained unclear whether additional regulatory elements remain undiscovered. In this study, we use chromatin profiling of pro-B cells to define 38 epigenetic states in mouse Ag receptor loci, each of which reflects a distinct regulatory po ...[more]

PMID: 24353267

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