Expression data from malignant human B-cell cell lines
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Steffen Larsen
PROVIDER: E-GEOD-53798 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Predicting response to multidrug regimens in cancer patients using cell line experiments and regularised regression models.
Falgreen Steffen S Dybkær Karen K Young Ken H KH Xu-Monette Zijun Y ZY El-Galaly Tarec C TC Laursen Maria Bach MB Bødker Julie S JS Kjeldsen Malene K MK Schmitz Alexander A Nyegaard Mette M Johnsen Hans Erik HE Bøgsted Martin M
BMC cancer 20150408
<h4>Background</h4>Patients suffering from cancer are often treated with a range of chemotherapeutic agents, but the treatment efficacy varies greatly between patients. Based on recent popularisation of regularised regression models the goal of this study was to establish workflows for pharmacogenomic predictors of response to standard multidrug regimens using baseline gene expression data and origin specific cell lines. The proposed workflows are tested on diffuse large B-cell lymphoma treated ...[more]
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