Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Whole blood DNA methylation samples from HIV positive men [2013 study]

ABSTRACT: Genome wide DNA methylation profiles of whole blood from HIV positive men. The Illumina Infinium 450k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 480,000 CpGs. Dataset included 120 subjects from the USA but because of missing clinical characteristics only 109 subjects were used in the scientific publication. The study analyzed the effect of HIV viral load on host DNA methylation levels. Bisulphite converted DNA from the 120 HIV positive men were hybridised to the Illumina Infinium 450k Human Methylation Beadchip. Subjects had different levels of HIV viral load. This dataset reports DNA methylation data set on 120 subjects that were generated in 2013 (while the other data set of 24 subjects reports DNA methylation data generated in 2012). Details on what each sample characteristics and their values represent are provided in the 'characteristics_readme.txt' file.

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Horvath 

PROVIDER: E-GEOD-53840 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to as an "epigenetic clock") to study the relationship between high body mass index (BMI) and the DNA methylation ages of human blood, liver, muscle, and adipose tissue. A significant correlation between BMI and epigenetic age acceleration could only be observed for liver (r = 0.42, P = 6.8 × 10(-4) in dataset 1  ...[more]

Similar Datasets

Transcriptomics Whole blood DNA methylation samples from HIV positive men [2012 study]
2015-06-09 | E-GEOD-53841 | biostudies-arrayexpress
Methylation profiling Whole blood DNA methylation samples from HIV positive men [2013 study]
2014-11-03 | GSE53840 | GEO
Methylation profiling Whole blood DNA methylation samples from HIV positive men [2012 study]
2015-06-09 | GSE53841 | GEO
Methylation profiling DNA methylation levels of various brain regions from HIV+ and HIV- subjects
2015-06-09 | GSE59457 | GEO
Transcriptomics Cerebellum Illumina Inf 450 DNA methylation samples from HIV+ and HIV- human subjects
2015-06-09 | E-GEOD-67748 | biostudies-arrayexpress
Transcriptomics Frontal lobe (brain) Illumina Inf 450 DNA methylation samples from HIV+ and HIV- human subjects
2015-06-09 | E-GEOD-67749 | biostudies-arrayexpress
Transcriptomics DNA methylation levels of various brain regions from HIV+ and HIV- subjects
2015-06-09 | E-GEOD-59457 | biostudies-arrayexpress
Methylation profiling Cerebellum Illumina Inf 450 DNA methylation samples from HIV+ and HIV- human subjects
2015-06-09 | GSE67748 | GEO
Methylation profiling Blood Illumina Inf 450 DNA methylation samples from HIV+ and HIV- human subjects
2015-06-09 | GSE67751 | GEO
Methylation profiling Frontal lobe (brain) Illumina Inf 450 DNA methylation samples from HIV+ and HIV- human subjects
2015-06-09 | GSE67749 | GEO