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Frontal lobe (brain) Illumina Inf 450 DNA methylation samples from HIV+ and HIV- human subjects

ABSTRACT: Genome wide DNA methylation profiles of Frontal Lobe from HIV positive and HIV negative human subjects. The Illumina Infinium 450k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 486,000 CpGs. Dataset included 33 subjects from the USA. The epigenetic clock software (Horvath 2013) was used to measure epigenetic age acceleration effects and to relate them to HIV status. Bisulphite converted DNA from the 33 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip. 8 HIV+ subjects were compared to 25 HIV- subjects.

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Horvath

PROVIDER: E-GEOD-67749 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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HIV-1 Infection Accelerates Age According to the Epigenetic Clock.

Horvath Steve S Levine Andrew J AJ

The Journal of infectious diseases 20150512 10

<h4>Background</h4>Infection with human immunodeficiency virus type 1 (HIV) is associated with clinical symptoms of accelerated aging, as evidenced by the increased incidence and diversity of age-related illnesses at relatively young ages and supporting findings of organ and cellular pathologic analyses. But it has been difficult to detect an accelerated aging effect at a molecular level.<h4>Methods</h4>Here, we used an epigenetic biomarker of aging based on host DNA methylation levels to study ...[more]

PMID: 25969563

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