Chromatin occupancy and target genes of TCF7L2 in hepatocytes
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Sami Heikkinen
PROVIDER: E-GEOD-53862 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells.
Norton Luke L Chen Xi X Fourcaudot Marcel M Acharya Nikhil K NK DeFronzo Ralph A RA Heikkinen Sami S
Nucleic acids research 20141120 22
In the liver Wnt-signaling contributes to the metabolic fate of hepatocytes, but the precise role of the TCF7L2 in this process is unknown. We employed a temporal RNA-Seq approach to examine gene expression 3-96 h following Tcf7l2 silencing in rat hepatoma cells, and combined this with ChIP-Seq to investigate mechanisms of target gene regulation by TCF7L2. Silencing Tcf7l2 led to a time-dependent appearance of 406 differentially expressed genes (DEGs), including key regulators of cellular growth ...[more]
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