Unknown,Transcriptomics,Genomics,Proteomics

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ChIP-chip from lymph node-derived primary lymphocytes with anti-E2F2 and anti-SV40TAg


ABSTRACT: E2F2 is essential for the maintenance of T lymphocyte quiescence. To identify the full set of E2F2 target genes, and to gain further understanding of the role of E2F2 in transcriptional regulation, we have performed ChIP-chip analyses across the genome of lymph node-derived T lymphocytes. Here we show that during quiescence, E2F2 binds the promoters of a large number of genes involved in DNA metabolism and cell cycle regulation, concomitant with their transcriptional silencing. We performed 3 ChIP-chip experiments with an antibody against E2F2 and another 3 ChIP-chip experiments with an antibody against SV40TAg (irrelevant antibody).

ORGANISM(S): Mus musculus

SUBMITTER: Usue Laresgoiti 

PROVIDER: E-GEOD-53888 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes.

Laresgoiti Usua U   Apraiz Aintzane A   Olea Miguel M   Mitxelena Jone J   Osinalde Nerea N   Rodriguez José A JA   Fullaondo Asier A   Zubiaga Ana M AM  

Nucleic acids research 20130912 22


E2F2 is essential for the maintenance of T lymphocyte quiescence. To identify the full set of E2F2 target genes, and to gain further understanding of the role of E2F2 in transcriptional regulation, we have performed ChIP-chip analyses across the genome of lymph node-derived T lymphocytes. Here we show that during quiescence, E2F2 binds the promoters of a large number of genes involved in DNA metabolism and cell cycle regulation, concomitant with their transcriptional silencing. A comparison of C  ...[more]

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