Unknown,Transcriptomics,Genomics,Proteomics

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Dose response analysis of monophthalates in the murine embryonic stem cell test


ABSTRACT: Three embryotoxic phthalate monoesters, monobutyl phthalate (MBuP), monobenzyl phthalate (MBzP) and mono-(2-ethylhexyl) phthalate (MEHP) and the non-embryotoxic monomethyl phthalate (MMP) were studied for their effects on gene expression at several concentrations that did not induce cytotoxicity. 192 arrays

ORGANISM(S): Mus musculus

SUBMITTER: Jeroen Pennings 

PROVIDER: E-GEOD-53969 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A statistical approach towards the derivation of predictive gene sets for potency ranking of chemicals in the mouse embryonic stem cell test.

Schulpen Sjors H W SH   Pennings Jeroen L A JL   Tonk Elisa C M EC   Piersma Aldert H AH  

Toxicology letters 20140127 3


The embryonic stem cell test (EST) is applied as a model system for detection of embryotoxicants. The application of transcriptomics allows a more detailed effect assessment compared to the morphological endpoint. Genes involved in cell differentiation, modulated by chemical exposures, may be useful as biomarkers of developmental toxicity. We describe a statistical approach to obtain a predictive gene set for toxicity potency ranking of compounds within one class. This resulted in a gene set bas  ...[more]

Publication: 1/2

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