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Ste18p is a positive control element in the mating process of Candida albicans

ABSTRACT: Disruption of STE18 gene which encodes a Î³ subunit of a heterotrimeric G protein in Candida albicans is shown to block pheromone-induced gene expression. Ectopic expression of either the GÎ± or the GÎ² subunit of the heterotrimeric G protein is able to restore pheromone-induced gene expression. The transcriptional response to pheromone treatment was measured in the wild type strain, in a strain deleted for STE18, and in STE18 deleted strains ectopic expressing either the GÎ± or the GÎ² subunit of G protein in opaque forms under RT.

ORGANISM(S): Candida albicans

SUBMITTER: Yuan Sun

PROVIDER: E-GEOD-54031 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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