Expression data from Sin3Bp+/-KRaspG12D and Sin3Bp-/-KRaspG12D pancreata and from cultured primary pancreatic duct epithelial cells (PDEC) of the same genotype.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is strikingly resistant to conventional approaches. In this study, we report that the histone deacetylase associated SIN3B protein is required for activated KRAS-induced senescence in vivo using a mouse model of pancreatic cancer. We used microarray data to determine if SIN3B regulates KRAS-induced expression of the inflammatory response. Total RNA from Sin3Bp+/-KRaspG12D and Sin3Bp-/-KRaspG12D pancreas (two pancreata for each genotype) or PDEC (one for each genotype) was extracted and hybridized on Affymtrix microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Richard Graveline 

PROVIDER: E-GEOD-54197 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress