Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Boris Greber
PROVIDER: E-GEOD-5435 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Greber Boris B Lehrach Hans H Adjaye James J
Stem cells (Dayton, Ohio) 20061012 2
Fibroblast growth factor 2 (FGF2) is known to promote self-renewal of human embryonic stem cells (hESCs). In addition, it has been shown that transforming growth factor beta (TGFbeta) signaling is crucial in that the TGFbeta/Activin/Nodal branch of the pathway needs to be activated and the bone morphogenic protein (BMP)/GDF branch repressed to prevent differentiation. This holds particularly true for Serum Replacement-based medium containing BMP-like activity. We have reinvestigated a widely use ...[more]