Unknown,Transcriptomics,Genomics,Proteomics

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FGF2 stimulation experiment with CD1 mouse embryonic fibroblasts


ABSTRACT: Mouse embryonic fibroblasts stimulated with 40 ng/ml of FGF2 in conventional hES cell medium were analysed on whole-genome expression chips to reveal altered expression of genes encoding secreted proteins. as detailed for the individual samples

ORGANISM(S): Mus musculus

SUBMITTER: Boris Greber 

PROVIDER: E-GEOD-5435 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal.

Greber Boris B   Lehrach Hans H   Adjaye James J  

Stem cells (Dayton, Ohio) 20061012 2


Fibroblast growth factor 2 (FGF2) is known to promote self-renewal of human embryonic stem cells (hESCs). In addition, it has been shown that transforming growth factor beta (TGFbeta) signaling is crucial in that the TGFbeta/Activin/Nodal branch of the pathway needs to be activated and the bone morphogenic protein (BMP)/GDF branch repressed to prevent differentiation. This holds particularly true for Serum Replacement-based medium containing BMP-like activity. We have reinvestigated a widely use  ...[more]

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