Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Shau-Ping Lin
PROVIDER: E-GEOD-54411 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Liao Hung-Fu HF Chen Wendy S C WS Chen Yu-Hsiang YH Kao Tzu-Hao TH Tseng Yen-Tzu YT Lee Chien-Yueh CY Chiu Yu-Chiao YC Lee Pei-Lung PL Lin Qian-Jia QJ Ching Yung-Hao YH Hata Kenichiro K Cheng Winston T K WT Tsai Mong-Hsun MH Sasaki Hiroyuki H Ho Hong-Nerng HN Wu Shinn-Chih SC Huang Yen-Hua YH Yen Pauline P Lin Shau-Ping SP
Development (Cambridge, England) 20140521 12
The ability of adult stem cells to reside in a quiescent state is crucial for preventing premature exhaustion of the stem cell pool. However, the intrinsic epigenetic factors that regulate spermatogonial stem cell quiescence are largely unknown. Here, we investigate in mice how DNA methyltransferase 3-like (DNMT3L), an epigenetic regulator important for interpreting chromatin context and facilitating de novo DNA methylation, sustains the long-term male germ cell pool. We demonstrated that stem c ...[more]