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Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency

ABSTRACT: We found that Dnmt3l-KO donor cells display decreased levels of H3K9me3 and H3K27me3 accumulation, higher level of active histone mark H3K27ac and increased cytoplasmic localization of HDAC1, implicating a permissive epigenetic state beneficial for nuclear reprogramming. To investigate the gene expression profiles of MEFs and to find out the potential genes responsible for the improvement of Dnmt3l-KO cloned embryos.

ORGANISM(S): Mus musculus

SUBMITTER: Shau-Ping Lin

PROVIDER: E-GEOD-69007 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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