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Tg(actb2:KIT-D816V) transgenic zebrafish versus wild-type at 28 hpf

ABSTRACT: Transcriptional profiling of 28 hpf zebrafish transgenic expressing human KIT-D816V mutant gene versus wild-type embryos was performed. The aim of this experiment was to determine the expression changes caused by expression of KIT-D816V oncogene. This transgenic zebrafish represents a model of systemic mastocytosis with many features of this disease present in adults, but no very clear phenotypes in embryos. Thus, we attempted to determine if there are certain expression changes, which can be used as molecular features of active KIT expressed in these embryos. Two-condition experiment, Tg(actb2:KIT-D816V) versus wild-type(AB), 4 replicate experiments with a dye-swap each time

ORGANISM(S): Danio rerio

SUBMITTER: Sergey Prykhozhij

PROVIDER: E-GEOD-54613 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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