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DNA methylation profiles in primary cutaneous melanoma are associated with clinically significant pathologic features

ABSTRACT: We investigated whether methylation in primary melanomas is associated with tumor pathologic features or defines subgroups of primary melanomas 47 primary cutaneous melanomas were analyzed using the Illumina GoldenGate Cancer Panel I methylation array

ORGANISM(S): Homo sapiens

SUBMITTER: Nathaniel Slater

PROVIDER: E-GEOD-54623 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma.

Carson Craig C CC Moschos Stergios J SJ Edmiston Sharon N SN Darr David B DB Nikolaishvili-Feinberg Nana N Groben Pamela A PA Zhou Xin X Kuan Pei Fen PF Pandey Shaily S Chan Keefe T KT Jordan Jamie L JL Hao Honglin H Frank Jill S JS Hopkinson Dennis A DA Gibbs David C DC Alldredge Virginia D VD Parrish Eloise E Hanna Sara C SC Berkowitz Paula P Rubenstein David S DS Miller C Ryan CR Bear James E JE Ollila David W DW Sharpless Norman E NE Conway Kathleen K Thomas Nancy E NE

Clinical cancer research : an official journal of the American Association for Cancer Research 20150501 9

<h4>Purpose</h4>IL2 inducible T-cell kinase (ITK) promoter CpG sites are hypomethylated in melanomas compared with nevi. The expression of ITK in melanomas, however, has not been established and requires elucidation.<h4>Experimental design</h4>An ITK-specific monoclonal antibody was used to probe sections from deidentified, formalin-fixed paraffin-embedded tumor blocks or cell line arrays and ITK was visualized by IHC. Levels of ITK protein differed among melanoma cell lines and representative l ...[more]

PMID: 25934889

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