Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Fatima Al-Shahrour
PROVIDER: E-GEOD-54646 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rampal Raajit R Al-Shahrour Fatima F Abdel-Wahab Omar O Patel Jay P JP Brunel Jean-Philippe JP Mermel Craig H CH Bass Adam J AJ Pretz Jennifer J Ahn Jihae J Hricik Todd T Kilpivaara Outi O Wadleigh Martha M Busque Lambert L Gilliland D Gary DG Golub Todd R TR Ebert Benjamin L BL Levine Ross L RL
Blood 20140416 22
Genomic studies have identified somatic alterations in the majority of myeloproliferative neoplasms (MPN) patients, including JAK2 mutations in the majority of MPN patients and CALR mutations in JAK2-negative MPN patients. However, the role of JAK-STAT pathway activation in different MPNs, and in patients without JAK2 mutations, has not been definitively delineated. We used expression profiling, single nucleotide polymorphism arrays, and mutational profiling to investigate a well-characterized c ...[more]