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Transcriptional changes taking place during differentiation of H460-derived CSCs

ABSTRACT: Cancer Stem Cells derived from from human non-small cells lung cancer (NSCLC) H460 cells were differentiated by culturing them in the presence of Foetal Bovine Serum under adherent conditions. Changes in gene expression profiles were determined at 3, 9 and 24 hours of differentiation Expression profiles were determined for H460C cells undifferentiated of after 3, 9 and 24 hours of differentiation. Each sample type was hybridized to in-situ oligonucleotide microarrays (Agilent-014850 Whole Human Genome Microarray 4x44K). One channel per slide. Each differentiated population was compared to undifferentiated cells. Biological replicates: 2

ORGANISM(S): Homo sapiens

SUBMITTER: Juan Oliveros 

PROVIDER: E-GEOD-54712 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cancer stem cells and cisplatin-resistant cells isolated from non-small-lung cancer cell lines constitute related cell populations.

Lopez-Ayllon Blanca D BD   Moncho-Amor Veronica V   Abarrategi Ander A   Ibañez de Cáceres Inmaculada I   Castro-Carpeño Javier J   Belda-Iniesta Cristobal C   Perona Rosario R   Sastre Leandro L  

Cancer medicine 20140625 5

Lung cancer is the top cause of cancer-related deceases. One of the reasons is the development of resistance to the chemotherapy treatment. In particular, cancer stem cells (CSCs), can escape treatment and regenerate the bulk of the tumor. In this article, we describe a comparison between cancer cells resistant to cisplatin and CSCs, both derived from the non-small-cell lung cancer cell lines H460 and A549. Cisplatin-resistant cells were obtained after a single treatment with the drug. CSCs were  ...[more]

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