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Expression data from TGFBR3 controls and TGFBR3 knockdown of SUM159 3D cultures


ABSTRACT: The objective of this experiment was to determine global gene expression change in triple negative cell line upon knockdown of TGFBR3. Genotype specific differences in expression profiles have been evaluated using human HuGene1.0-ST affymetrix array. RNA was extracted from SUM159 controls and SUM159 TGFBR3KD cells cultured in 3-dimensional in vitro system. Control (N=3) and TGFBR3KD (N=3) samples were hybridized to the Human gene 1.0 ST array, scanned with Affymetrix using AGCC v. 3.2.4 and then analyzed in R 3.0.1 using the oligo package.

ORGANISM(S): Homo sapiens

SUBMITTER: Harold Moses 

PROVIDER: E-GEOD-54756 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer.

Jovanović Bojana B   Beeler J Scott JS   Pickup Michael W MW   Chytil Anna A   Gorska Agnieszka E AE   Ashby William J WJ   Lehmann Brian D BD   Zijlstra Andries A   Pietenpol Jennifer A JA   Moses Harold L HL  

Breast cancer research : BCR 20140701 4


<h4>Introduction</h4>There is a major need to better understand the molecular basis of triple negative breast cancer (TNBC) in order to develop effective therapeutic strategies. Using gene expression data from 587 TNBC patients we previously identified six subtypes of the disease, among which a mesenchymal-stem like (MSL) subtype. The MSL subtype has significantly higher expression of the transforming growth factor beta (TGF-β) pathway-associated genes relative to other subtypes, including the T  ...[more]

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