Whole genome profiling of whole liver lysates of vehicle and Sorafenib-treated iAST mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Anja Runge
PROVIDER: E-GEOD-54857 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice.
Runge Anja A Hu Junhao J Wieland Matthias M Bergeest Jan-Philip JP Mogler Carolin C Neumann André A Géraud Cyrill C Arnold Bernd B Rohr Karl K Komljenovic Dorde D Schirmacher Peter P Goerdt Sergij S Augustin Hellmut G HG
Cancer research 20140606 15
The limited availability of experimental tumor models that faithfully mimic the progression of human tumors and their response to therapy remains a major bottleneck to the clinical translation and application of novel therapeutic principles. To address this challenge in hepatocellular carcinoma (HCC), one of the deadliest and most common cancers in the world, we developed and validated an inducible model of hepatocarcinogenesis in adult mice. Tumorigenesis was triggered by intravenous adenoviral ...[more]
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