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MRNA expression in blood of 18 schizophrenia patients and 12 healthy controls

ABSTRACT: The study profiles genome-wide mRNA expression in blood from 18 early-onset SZ (EOS) cases and 12 healthy controls. A total of 1070 mRNAs were detected by the microarrays in our samples. 18 schizophrenia samples and 12 healthy controls were used to acquire blood expression profiles

ORGANISM(S): Homo sapiens

SUBMITTER: Fuquan Zhang

PROVIDER: E-GEOD-54913 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Converging evidence implicates the abnormal microRNA system in schizophrenia.

Zhang Fuquan F Xu Yong Y Shugart Yin Yao YY Yue Weihua W Qi Guoyang G Yuan Guozhen G Cheng Zaohuo Z Yao Jianjun J Wang Jidong J Wang Guoqiang G Cao Hongbao H Guo Wei W Zhou Zhenhe Z Wang Zhiqiang Z Tian Lin L Jin Chunhui C Yuan Jianmin J Liu Chenxing C Zhang Dai D

Schizophrenia bulletin 20141126 3

<h4>Background</h4>Previous findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation of brain development through microRNA (miRNA) systems.<h4>Methods</h4>This study aims to (1) compare the overall frequency of 121 rare variants (RVs) in 59 genes associated with the miRNA system in genome-wide association studies (GWAS)-derived data including 768 SZ cases and 1348 healthy controls and validated in ...[more]

PMID: 25429046

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mRNA expression in blood of 18 schizophrenia patients and 12 healthy controls

Project description:The study profiles genome-wide mRNA expression in blood from 18 early-onset SZ (EOS) cases and 12 healthy controls. A total of 1070 mRNAs were detected by the microarrays in our samples.

2014-12-05 | GSE54913 | GEO

miRNA expression in blood of 15 schizophrenia patients and 15 healthy controls

Project description:The study profiles genome-wide miRNA expression in blood from 15 early-onset SZ (EOS) cases and 15 healthy controls. A total of 1070 miRNAs were detected by the microarrays in our samples. We profiles miRNA expression in 15 schizophrenia samples and 15 healthy controls to explore the alteration of miRNAs in schizophrenia.

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Expression in blood of schizophrenia patients and healthy controls

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Transcriptomic analysis of WT versus Ikzf4-/- CD4+ T cells cultured in Th2-polarizing conditions

Project description:The Ikaros zinc finger transcription factor Eos has been commonly implicated in regulatory T cells to promote their immunosuppressive functions. Paradoxically, a new role is emerging for Eos in promoting pro-inflammatory responses of conventional CD4+ T cells in the dysregulated setting of autoimmunity. Even so, the precise role of Eos in regulating the differentiation and function of healthy effector CD4+ T cell subsets remains unclear. Here, we find that Eos is a positive regulator of CD4+ T helper 2 (TH2) cells—effector T cells implicated in the induction of allergic asthma. Using murine in vitro TH2 cells and an in vivo house dust mite asthma model, we found that Eos-deficient T cells had reduced expression of key TH2 transcription factors, effector cytokines, and differentiation receptors. Mechanistically, among various TH2-polarizing pathways, the IL-2/STAT5 axis and its downstream TH2 gene targets emerged as one of the most significantly downregulated networks in Eos deficiency. Using in vitro TH2 cells and overexpression of Eos zinc-finger-domain mutants, we discovered that Eos forms a novel complex with and supports the tyrosine-phosphorylated signaling activity of STAT5. Overall, these data define a novel regulatory mechanism whereby Eos promotes IL-2/STAT5 activity to facilitate TH2 differentiation.

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lncRNA expression profiles for preterm premature rupture of membrane (PPROM)

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