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Expression in blood of schizophrenia patients and healthy controls

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Fuquan Zhang

PROVIDER: E-GEOD-54914 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Converging evidence implicates the abnormal microRNA system in schizophrenia.

Zhang Fuquan F Xu Yong Y Shugart Yin Yao YY Yue Weihua W Qi Guoyang G Yuan Guozhen G Cheng Zaohuo Z Yao Jianjun J Wang Jidong J Wang Guoqiang G Cao Hongbao H Guo Wei W Zhou Zhenhe Z Wang Zhiqiang Z Tian Lin L Jin Chunhui C Yuan Jianmin J Liu Chenxing C Zhang Dai D

Schizophrenia bulletin 20141126 3

<h4>Background</h4>Previous findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation of brain development through microRNA (miRNA) systems.<h4>Methods</h4>This study aims to (1) compare the overall frequency of 121 rare variants (RVs) in 59 genes associated with the miRNA system in genome-wide association studies (GWAS)-derived data including 768 SZ cases and 1348 healthy controls and validated in ...[more]

PMID: 25429046

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