Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Qiuhua Huang
PROVIDER: E-GEOD-54931 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhang Yuanliang Y Xie Shugao S Zhou Yan Y Xie Yinyin Y Liu Ping P Sun Mingming M Xiao Huasheng H Jin Ying Y Sun Xiaojian X Chen Zhu Z Huang Qiuhua Q Chen Saijuan S
Cell reports 20140918 6
Setd2 is known as a histone-H3K36-specific methyltransferase. However, its role in physiological function remains unclear. In this study, we show that Setd2 mainly regulates differentiation of murine embryonic stem cells (mESCs) toward primitive endoderm. Furthermore, we show that downregulated endoderm-related genes in Setd2(-/-) mESCs are associated with an aberrantly low level of Erk activity and that enforced expression of Fgfr3 can rescue the defective Erk pathway in Setd2(-/-) mESCs. Inter ...[more]