Basal Cell Carcinoma Tumor-derived Fibroblasts
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Julie Sneddon
PROVIDER: E-GEOD-5502 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.
Sneddon Julie B JB Zhen Hanson H HH Montgomery Kelli K van de Rijn Matt M Tward Aaron D AD West Robert R Gladstone Hayes H Chang Howard Y HY Morganroth Greg S GS Oro Anthony E AE Brown Patrick O PO
Proceedings of the National Academy of Sciences of the United States of America 20060926 40
Although tissue microenvironments play critical roles in epithelial development and tumorigenesis, the factors mediating these effects are poorly understood. In this work, we used a genomic approach to identify factors produced by cells in the microenvironment of basal cell carcinoma (BCC) of the skin, one of the most common human cancers. The global gene expression programs of stromal cell cultures derived from human BCCs showed consistent, systematic differences from those derived from nontumo ...[more]
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