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Effect of chronic valproic acid treatment on hepatic gene expression profile in Wfs1 knockout mouse.

ABSTRACT: Aim of the present study was to compare the effect of chronic VPA treatment in wild type and Wfs1 knockout mice on hepatic gene expression profile. Wild type, Wfs1 heterozygous and homozygous mice were treated with VPA for three months (300 mg/kg i.p. daily) and gene expression profiles in liver were evaluated using Affymetrix Mouse GeneChip 1.0 st arrays. male wild-type and Wfs1 mutant (+/- and -/-) mice were treated with valproic acid (300 mg/kg/day i.p.) or vehicle (saline, 10ml/kg i.p.) for 12 weeks starting from age 4 to 6 weeks. At age 16 to 18 weeks mice were killed, RNA extracted from the liver and analysed using Affymetrix Mouse Gene 1.0 ST Arrays. Expression of few genes was verified using RT-PCR. There were 8 animals in every group, 48 animals total.

ORGANISM(S): Mus musculus

SUBMITTER: Anton Terasmaa

PROVIDER: E-GEOD-55143 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Effect of chronic valproic acid treatment on hepatic gene expression profile in Wfs1 knockout mouse.

Project description:Aim of the present study was to compare the effect of chronic VPA treatment in wild type and Wfs1 knockout mice on hepatic gene expression profile. Wild type, Wfs1 heterozygous and homozygous mice were treated with VPA for three months (300 mg/kg i.p. daily) and gene expression profiles in liver were evaluated using Affymetrix Mouse GeneChip 1.0 st arrays.

2014-02-20 | GSE55143 | GEO

VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome

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Transcription profiling of mouse livers of adult and newborn animal response to Aflatoxin B1

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2009-01-14 | E-GEOD-4740 | biostudies-arrayexpress

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2008-11-25 | E-GEOD-10166 | biostudies-arrayexpress

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