Transcription profiling of liver from Wistar rats treated with either pentadecafluoro-octanoic acid (PFOA) or 1H,1H,2H,2H-heptadecafluorodecan-1-ol (8:2 FTOH)
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ABSTRACT: Wistar rats were treated with either PFOA or 8:2 FTOH for 10 days with the following doses, 3, 10 or 25 mg/kg Bwt, followed by one recovery day. The treatment was given daily by i.p. injections. The rats were humanly sacrificed by decapitation, and the liver was immediatly dissected and divided, one piece of the liver was sumerged in RNALater (for use in microarray and realtime experiments) and the other piece of liver was submerged in cold buffer(for ezymatic assays). Pentadecafluorooctanoic (Perfluorooctanoic acid, PFOA) acid is an industrial surfactant. 8:2 FTOH is a fluorotelomer alcohol.
INSTRUMENT(S): ScanArray Lite [PerkinElmer]
ORGANISM(S): Rattus norvegicus
SUBMITTER: Maria Landin
PROVIDER: E-MEXP-1045 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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