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Unknown,Transcriptomics,Genomics,Proteomics

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JNK-mediated control of gene expression in liver

ABSTRACT: RNAseq analysis of gene expression in Liver of Control and JNK deficient mice fed a control or a High fat diet Contro(Albcre+)l and mice with liver-specific defiency of JNK (Alb Cre+ Jnk1flox/flox, Jnk2flox/flox or Jnk1flox/floxJnk2flox/flox) were fed a control or a high fat diet for 16 weeks. Gene expression analysis in liver was analyzed by RNAseq

ORGANISM(S): Mus musculus

SUBMITTER: Roger Davis

PROVIDER: E-GEOD-55190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway.

Vernia Santiago S Cavanagh-Kyros Julie J Garcia-Haro Luisa L Sabio Guadalupe G Barrett Tamera T Jung Dae Young DY Kim Jason K JK Xu Jia J Shulha Hennady P HP Garber Manuel M Gao Guangping G Davis Roger J RJ

Cell metabolism 20140717 3

The cJun NH2-terminal kinase (JNK) stress signaling pathway is implicated in the metabolic response to the consumption of a high-fat diet, including the development of obesity and insulin resistance. These metabolic adaptations involve altered liver function. Here, we demonstrate that hepatic JNK potently represses the nuclear hormone receptor peroxisome proliferator-activated receptor α (PPARα). Therefore, JNK causes decreased expression of PPARα target genes that increase fatty acid oxidation ...[more]

PMID: 25043817

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JNK-mediated control of gene expression in liver

Project description:RNAseq analysis of gene expression in Liver of Control and JNK deficient mice fed a control or a High fat diet

2015-03-06 | GSE55190 | GEO

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Shp-deletion induces dissociation of steatosis and inflammation in NASH

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2019-12-10 | GSE133566 | GEO

Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [IWAT]

Project description:Analysis of subcutaneous adipose tissue (IWAT) from Yin Yang 1 brown fat specific knockout mice fed a high fat diet for 2 weeks. The goal was to identify a gene signature of IWAT browning in YY1 mutant mice. Control mice YY1flox/flox versus YY1flox/flox; Ucp1Cre were fed a high fat diet for 2 weeks

2015-11-10 | E-GEOD-68382 | biostudies-arrayexpress

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Project description:To gain insight into the role of testosterone in modulating hepatic fat accumulation, we collected liver tissues from high fat diet-fed intact male pigs, castrated male pigs, and castrated male pigs with testosterone replacement. RNA-Seq was employed to profile hepatic gene expression in pigs with different testosterone levels. Liver mRNA profiles of intact male pigs fed a HFC diet, castrated male pigs fed a HFC diet, and castrated male pigs treated with testosterone fed a HFC diet were generated by deep sequencing, using Illumina HiSeq 2000.

2015-01-08 | E-GEOD-62696 | biostudies-arrayexpress

Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [BAT]

Project description:Analysis of brown adipose tissue from Yin Yang 1 (YY1) brown fat specific knockout mice fed a high fat diet for 3 months. YY1 deficiency in brown adipose tissue leads to strong thermogenic deficiency. The goal was to identify the genes controlled by YY1 responsible of brown fat defective function. Control mice YY1flox/flox versus YY1flox/flox; Ucp1Cre were fed a high fat diet for 3 months

2015-11-10 | E-GEOD-68429 | biostudies-arrayexpress

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2015-09-01 | E-GEOD-66557 | biostudies-arrayexpress

Genome-wide expression profile of livers from mice fed HFD,SO-HFD or Viv chow [RNAseq]

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2015-08-28 | E-GEOD-68360 | biostudies-arrayexpress

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