Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Minho Kang
PROVIDER: E-GEOD-55214 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lee Dong Chul DC Sohn Hyun Ahm HA Park Zee-Yong ZY Oh Sangho S Kang Yun Kyung YK Lee Kyoung-Min KM Kang Minho M Jang Ye Jin YJ Yang Suk-Jin SJ Hong Young Ki YK Noh Hanmi H Kim Jung-Ae JA Kim Dong Joon DJ Bae Kwang-Hee KH Kim Dong Min DM Chung Sang J SJ Yoo Hyang Sook HS Yu Dae-Yeul DY Park Kyung Chan KC Yeom Young Il YI
Cell 20150416 3
Organisms must be able to respond to low oxygen in a number of homeostatic and pathological contexts. Regulation of hypoxic responses via the hypoxia-inducible factor (HIF) is well established, but evidence indicates that other, HIF-independent mechanisms are also involved. Here, we report a hypoxic response that depends on the accumulation of lactate, a metabolite whose production increases in hypoxic conditions. We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normo ...[more]