Unknown,Transcriptomics,Genomics,Proteomics

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Effect of NDRG3 over-expression and knockdown on cell response to hypoxia


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Minho Kang 

PROVIDER: E-GEOD-55214 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Organisms must be able to respond to low oxygen in a number of homeostatic and pathological contexts. Regulation of hypoxic responses via the hypoxia-inducible factor (HIF) is well established, but evidence indicates that other, HIF-independent mechanisms are also involved. Here, we report a hypoxic response that depends on the accumulation of lactate, a metabolite whose production increases in hypoxic conditions. We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normo  ...[more]

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