Unknown,Transcriptomics,Genomics,Proteomics

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Genomewide analysis of QKI-dependent alternative splicing


ABSTRACT: To identify QKI targets, we performed QKI knockdown in BEAS2B cells and analyzed alternative splicing patterns by high-throughput RNA sequencing. The mRNA profiles of control- and QKI-knockdown BEAS2B cells were generated by deep sequencing using Illumina GAIIx sequencer.

ORGANISM(S): Homo sapiens

SUBMITTER: Jingyi Hui 

PROVIDER: E-GEOD-55215 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The RNA-binding protein QKI suppresses cancer-associated aberrant splicing.

Zong Feng-Yang FY   Fu Xing X   Wei Wen-Juan WJ   Luo Ya-Ge YG   Heiner Monika M   Cao Li-Juan LJ   Fang Zhaoyuan Z   Fang Rong R   Lu Daru D   Ji Hongbin H   Hui Jingyi J  

PLoS genetics 20140410 4


Lung cancer is the leading cause of cancer-related death worldwide. Aberrant splicing has been implicated in lung tumorigenesis. However, the functional links between splicing regulation and lung cancer are not well understood. Here we identify the RNA-binding protein QKI as a key regulator of alternative splicing in lung cancer. We show that QKI is frequently down-regulated in lung cancer, and its down-regulation is significantly associated with a poorer prognosis. QKI-5 inhibits the proliferat  ...[more]

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