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QKI and miR-155 in inflammation and leukemogenesis

ABSTRACT: Transcription profiling by array of siRNA against Quaking (QKI) transcripts to identify transcripts that are modulated by QKI activity. MiR-155 is an oncogene and we report here that it targets QKI transcripts. Therefore, we believe that QKI acts as a tumor suppressor gene in different leukemias. We ablated the expression of QKI transcripts using siRNAs in order to further elucidate the effects of QKI in leukemogenesis, and how miR-155 and QKI functionally interact with each other.

ORGANISM(S): Homo sapiens

SUBMITTER: Esmerina Tili

PROVIDER: E-MTAB-2375 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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