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RNA-seq from paired human CRC/control mucosa samples

ABSTRACT: We have used RNA-seq to examine gene expression from paired human CRC/control mucosa samples and identified CRC-specific expressed long noncoding RNAs To identify CRC-specific expressed genes, including long noncoding RNAs

ORGANISM(S): Homo sapiens

SUBMITTER: Li Yang

PROVIDER: E-GEOD-55259 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus.

Xiang Jian-Feng JF Yin Qing-Fei QF Chen Tian T Zhang Yang Y Zhang Xiao-Ou XO Wu Zheng Z Zhang Shaofeng S Wang Hai-Bin HB Ge Junhui J Lu Xuhua X Yang Li L Chen Ling-Ling LL

Cell research 20140325 5

The human 8q24 gene desert contains multiple enhancers that form tissue-specific long-range chromatin loops with the MYC oncogene, but how chromatin looping at the MYC locus is regulated remains poorly understood. Here we demonstrate that a long noncoding RNA (lncRNA), CCAT1-L, is transcribed specifically in human colorectal cancers from a locus 515 kb upstream of MYC. This lncRNA plays a role in MYC transcriptional regulation and promotes long-range chromatin looping. Importantly, the CCAT1-L l ...[more]

PMID: 24662484

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