Unknown,Transcriptomics,Genomics,Proteomics

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Comparison of the expression profiles of 630E strain and an Hfq antisense after 7.5h of growth in Tyt


ABSTRACT: Transcriptional profiling of C. difficile 630E strain vs. an Hfq antisense after 7.5h of growth inTYt. Two-conditions experiments, 630E strain vs. Hfq antisense grown in TYt, 4 biological replicates for each condition.

ORGANISM(S): Peptoclostridium difficile

SUBMITTER: Monot Marc 

PROVIDER: E-GEOD-55273 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Pleiotropic role of the RNA chaperone protein Hfq in the human pathogen Clostridium difficile.

Boudry P P   Gracia C C   Monot M M   Caillet J J   Saujet L L   Hajnsdorf E E   Dupuy B B   Martin-Verstraete I I   Soutourina O O  

Journal of bacteriology 20140630 18


Clostridium difficile is an emergent human pathogen and the most common cause of nosocomial diarrhea. Our recent data strongly suggest the importance of RNA-based mechanisms for the control of gene expression in C. difficile. In an effort to understand the function of the RNA chaperone protein Hfq, we constructed and characterized an Hfq-depleted strain in C. difficile. Hfq depletion led to a growth defect, morphological changes, an increased sensitivity to stresses, and a better ability to spor  ...[more]

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