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Genome wide analysis of copy number variation in NAFLD spectrum

ABSTRACT: Despite some success in identifying CNVs responsible for metabolic phenotypes including obesity and diabetes mellitus, there are as yet no data available to suggest whether or not CNVs might be involved in the etiology of the NAFLD spectrum. This report is a comprehensive analysis of copy number in Malaysian patients with NAFLD. Genomic DNA was extracted from blood obtained from patients with NAFLD and submitted for genome-wide analysis using aCGH

ORGANISM(S): Homo sapiens

SUBMITTER: shamsul mohd zain

PROVIDER: E-GEOD-55645 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide analysis of copy number variation identifies candidate gene loci associated with the progression of non-alcoholic fatty liver disease.

Zain Shamsul Mohd SM Mohamed Rosmawati R Cooper David N DN Razali Rozaimi R Rampal Sanjay S Mahadeva Sanjiv S Chan Wah-Kheong WK Anwar Arif A Rosli Nurul Shielawati Mohamed NS Mahfudz Anis Shafina AS Cheah Phaik-Leng PL Basu Roma Choudhury RC Mohamed Zahurin Z

PloS one 20140417 4

Between 10 and 25% of individuals with non-alcoholic fatty liver disease (NAFLD) develop hepatic fibrosis leading to cirrhosis and hepatocellular carcinoma (HCC). To investigate the molecular basis of disease progression, we performed a genome-wide analysis of copy number variation (CNV) in a total of 49 patients with NAFLD [10 simple steatosis and 39 non-alcoholic steatohepatitis (NASH)] and 49 matched controls using high-density comparative genomic hybridization (CGH) microarrays. A total of 1 ...[more]

PMID: 24743702

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