Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Athena Wong
PROVIDER: E-GEOD-557 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wong Athena W AW Brickey W June WJ Taxman Debra J DJ van Deventer Hendrick W HW Reed William W Gao Jian Xin JX Zheng Pan P Liu Yang Y Li Ping P Blum Janice S JS McKinnon Karen P KP Ting Jenny P-Y JP
Nature immunology 20030810 9
The major histocompatibility complex (MHC) class II transactivator (CIITA) is the 'master coactivator' of MHC class II genes. To identify new targets of CIITA, we analyzed cDNA microarrays of dendritic cells (DCs) from CIITA-deficient, MHC class II-deficient and control mice. We found the semaphorin receptor plexin-A1 was expressed in DCs, but not in other immune cells, and was strongly induced by CIITA. RNA interference by short hairpin RNA specific for plexin-A1, but not a single-nucleotide mu ...[more]