Ontology highlight
ABSTRACT:
SUBMITTER: Haspot F
PROVIDER: S-EPMC4045013 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20131204 1
Avoidance of long-term immunosuppression is a desired goal in organ transplantation. Mixed chimerism offers a promising approach to tolerance induction, and we have aimed to develop low-toxicity, nonimmunodepleting approaches to achieve this outcome. In a mouse model achieving fully MHC-mismatched allogeneic bone marrow engraftment with minimal conditioning (3 Gy total body irradiation followed by anti-CD154 and T cell-depleted allogeneic bone marrow cells), CD4 T cells in the recipient are requ ...[more]