Unknown,Transcriptomics,Genomics,Proteomics

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Dissection of estrogen receptor alpha signaling pathways in osteoblasts using RNA-sequencing


ABSTRACT: The goal is to identify estrogen-dependent gene expression patterns using RNAseq for 3 different ERα forms in human osteoblasts. We analyzed 3 different forms of estrogen receptor alpha (ERα), 1) Wild-type, 2) NERKI (DNA-binding mutant) and 3) NOER (Nuclear Only ERα, not membrane). Each was infected into hFOB (human osteoblast) cells and treated with either vehicle or E2 (10nM) (n=3 for each group/treatment). RNAseq was then performed.

ORGANISM(S): Homo sapiens

SUBMITTER: David Monroe 

PROVIDER: E-GEOD-55769 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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