Dissection of estrogen receptor alpha signaling pathways in osteoblasts using RNA-sequencing
Ontology highlight
ABSTRACT: The goal is to identify estrogen-dependent gene expression patterns using RNAseq for 3 different ERα forms in human osteoblasts. We analyzed 3 different forms of estrogen receptor alpha (ERα), 1) Wild-type, 2) NERKI (DNA-binding mutant) and 3) NOER (Nuclear Only ERα, not membrane). Each was infected into hFOB (human osteoblast) cells and treated with either vehicle or E2 (10nM) (n=3 for each group/treatment). RNAseq was then performed.
ORGANISM(S): Homo sapiens
SUBMITTER: David Monroe
PROVIDER: E-GEOD-55769 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
ACCESS DATA