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Transcription profiling of mouse neocortical and cerebellar astrocytes

ABSTRACT: Affymetrix Mouse Genome 430 2.0 GeneChip microarrays were used to analyze murine neocortical and cerbellar astrocytes generated from postnatal (PN) day 1 wild-type (ICR) pups. Experiment Overall Design: Three samples each of murine neocortical and cerebellar astrocytes were analyzed.

ORGANISM(S): Mus musculus

SUBMITTER: Mukesh Sharma

PROVIDER: E-GEOD-5582 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin.

Sharma Mukesh K MK Mansur David B DB Reifenberger Guido G Perry Arie A Leonard Jeffrey R JR Aldape Kenneth D KD Albin Meredith G MG Emnett Ryan J RJ Loeser Simon S Watson Mark A MA Nagarajan Rakesh R Gutmann David H DH

Cancer research 20070201 3

Pilocytic astrocytomas (PAs) are the most common glioma in children. Whereas many PAs are slow-growing or clinically indolent, others exhibit more aggressive features with tumor recurrence and death. To identify genetic signatures that might predict PA clinical behavior, we did gene expression profiling on 41 primary PAs arising sporadically and in patients with neurofibromatosis type 1 (NF1). Whereas no expression signature was found that could discriminate clinically aggressive or recurrent tu ...[more]

PMID: 17283119

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Neocortical and cerebellar astrocytes

Project description:Affymetrix Mouse Genome 430 2.0 GeneChip microarrays were used to analyze murine neocortical and cerbellar astrocytes generated from postnatal (PN) day 1 wild-type (ICR) pups. Keywords: neocortical astrocyte, cerebellar astrocyte, murine, postnatal day 1

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Temporally defined neocortical translation and polysome assembly is determined by the RNA-binding protein, Hu antigen R

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Yin Yang 1 sets up the stage for cerebellar astrocyte maturation

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