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Layer-specific molecular expression in neocortical astrocytes

ABSTRACT: Layer-specific molecular expression in neocortical astrocytes

OTHER RELATED OMICS DATASETS IN: GSE111916

PROVIDER: PRJNA438534 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6845024.fastq.gz	Fastqsanger.gz
	SRR6845025.fastq.gz	Fastqsanger.gz
	SRR6845026.fastq.gz	Fastqsanger.gz
	SRR6845027.fastq.gz	Fastqsanger.gz
	SRR6845028.fastq.gz	Fastqsanger.gz

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Layer-specific molecular expression in neocortical astrocytes

Project description:Protoplasmic astrocytes in layers II to VI of the mammalian neocortex have historically been thought to comprise a homogeneous population. Given that layer-specific neuronal subtypes play essential roles in cortical circuitry, astrocytes might also be expected to support and modify this circuitry in a layer-specific manner. In order to investigate whether protoplasmic astrocytes exhibit layer-specific heterogeneity, we compared the gene expression profiles of astrocytes between upper layers (layers II to IV) and deep layers (layers V and VI). Although most genes known to be preferentially expressed in astrocytes (astrocyte-enriched genes) were equally expressed between upper-layer astrocytes and deep-layer astrocytes, some such genes (astrocyte-enriched genes or genes with known function in astrocytes) were significantly enriched in upper-layer astrocytes or deep-layer astrocytes.

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