Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Sebastian Kadener
PROVIDER: E-GEOD-55872 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ashwal-Fluss Reut R Meyer Markus M Pamudurti Nagarjuna Reddy NR Ivanov Andranik A Bartok Osnat O Hanan Mor M Evantal Naveh N Memczak Sebastian S Rajewsky Nikolaus N Kadener Sebastian S
Molecular cell 20140918 1
Circular RNAs (circRNAs) are widely expressed noncoding RNAs. However, their biogenesis and possible functions are poorly understood. Here, by studying circRNAs that we identified in neuronal tissues, we provide evidence that animal circRNAs are generated cotranscriptionally and that their production rate is mainly determined by intronic sequences. We demonstrate that circularization and splicing compete against each other. These mechanisms are tissue specific and conserved in animals. Interesti ...[more]